Download Biochips: Technology and Applications by David Dorris, Chang-gong Liu, Ramesh Ramakrishnan, Richard PDF

By David Dorris, Chang-gong Liu, Ramesh Ramakrishnan, Richard Shippy (auth.), Dr. Wan-Li Xing, Dr. Jing Cheng (eds.)

This booklet brings jointly contributions from the world over popular specialists within the biochip box. those chapters current not just the authors' newest study paintings, but additionally speak about present traits in biochip know-how. particular issues comprise microarray know-how and its purposes, microfluidics, drug discovery, detection know-how, lab-on-chip know-how and bioinformatics. either beginners to the sphere and skilled biochip researchers will reap the benefits of this book.

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Extra resources for Biochips: Technology and Applications

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Introduction Understanding biological processes such as diseases initiation at the gene level is becomeing a hotspot in molecular biology. , may answer why these different stages occur. It is very important to screen out these special genes from the great amount of human genome. Conventional methods of northern or southern blot can not meet this requirement, but the advanced technique of DNA microarrays can do so. It allows monitoring the expression of thousands or tens of thousands of genes simultaneously in one hybridization experiment.

The potential scope of microchips in biological analysis is almost unlimited and will undoubtedly include most areas of laboratory medicine, biology and veterinary science. However, application of the technology will be limited by the ability to compete with non-microchip based devices in quality, cost and convenience. References Belgrader P, Benett W, Hadley D , Long G, Mariella Jr R, Milanovich F, Nasarabadi S, Nelson W, Richards J and Stratton P (1998) Clin Chern 44: 2191 Cheng J and Kricka LJ (eds) (2001) Biochip Technology, Gordon and Breach Scientific Publishers, Singapore Opportunities and Obstacles to the Routine Implementation of Microchips 49 Cheng J, Shoffner MA, Hvichia GE, Kricka LJ and Wilding P (1996) Nucleic Acids Res 24: 380 Chen YH and Chen SH (2000) Electrophoresis 21: 165 Chen YH, Wang WC, Young KC, Chang TT and Chen SH (1999) Clin Chern 45: 1938 Chiem NH and Harrison DJ (1998) Clin Chern 44:591 Colyer CL, Tang T, Chiem Nand Harrison DJ (1997) Electrophoresis 18: 1733 Dolnik V, Liu S and Jovanovich S (2000) Electrophoresis 21: 41 Eggers M and Ehrlich D ( 1995) Hematol Pathol 9: 1 Ekstrom S, Onnerfjord P, Nilsson J, Bengtsson M, Laurel!

In contrast to the engineering of biochip arrays with probing nucleic acids, the manufacturing of protein arrays requires novel technologies and immobilization approaches. Individual proteins differ significantly in molecular stability, surface charge, local surface polarity and many more physical and kinetic parameters. The expression of the individual biological function of proteins on material surfaces is often difficult to achieve, incidentially even for a single type of protein. In order to circumvent obstacles set by the molecular idiosyncrasies of proteins and biomolecules in general, tools and processes were designed for addressable immobilization of biomolecules including proteins on material surfaces.

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