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By Kurt Faber

This, the 6th variation of the verified textbook on biocatalysis, feeds into undergraduate and graduate classes in sleek natural chemistry, in addition being a concise creation to the sector. New fabric contains color pix and state of the art learn.

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Kragl U, Niedermeyer U, Kula M-R, Wandrey (1990) Ann NY Acad Sci 613:167 106. Voß H, Miethe P (1992) Enzymes entrapped in liquid crystals: a novel approach for biocatalysis in nonaqueous media. In: Tramper J, Vermae MH, Beet HH, Stockar UV (eds) Biocatalysis in non-conventional media, progress in biotechnology. Elsevier, London 8:739 107. Miethe P, Jansen I, Niedermeyer, Kragl U, Haftendorn R, Kula M-R, Mohr K-H, Meyer H-W (1992) Biocatalysis 7:61 108. Schmitz J (1992) PhD Thesis, University of Cologne 109.

Johnson · H. Griengl Fig. 1. A ribbon stereorepresentation of the Hnl from Hevea brasiliensis Fig. 2. A section through the surface representation of the Hnl crystal structure. A histidine molecule is shown in the active site identification of the active site and the determination of some of the residues participating in the enzyme catalysed formation of cyanohydrins by HbHnl. Consequent to this observed similarity, a sharp turn (“nucleophilic elbow”) between a b-sheet and an a-helix which contains serine80 as the central residue was also identified [46].

2 Chemical Transformations . . . . . . . . . . . . 49 Unsaturated Cyanohydrins . . . . . . . . . . . . 51 5 Conclusions and Outlook 6 References . . . . . . . . . . . . . . . . 53 . . . . . . . . . . . . g. biotransformations [1a–c, 2], will be very advantageous. In this respect, the hydroxynitrile lyases (Hnl) and their catalytic production of chiral cyanohydrins may have a significant role to play. The Hnls catalyse the asymmetric addition of hydrogen cyanide (HCN) to the carbonyl moiety of an aldehyde or ketone (Scheme 1) to yield a chiral cyanohydrin (1) (where R1 and R2 R1 = Alkyl or Aryl and R2 = H or Alkyl).

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