Download Recombinant DNA Technologies in Neuroendocrinology by D. Richter (auth.), Hiroo Imura M. D. (eds.) PDF

By D. Richter (auth.), Hiroo Imura M. D. (eds.)

This quantity covers new facets and destiny instructions in molecular neuroendocrinology, a massive and quickly turning out to be zone in neuroendocrinology. one of the numerous neurotransmitters or neuromodulators that play a massive position within the keep an eye on of endocrine capabilities, neuropeptides and comparable proteins have drawn certain recognition as a result of their range and complexity in motion. extra lately, molecular biology has turn into an important device of analysis during this sector. numerous genes encoding neuropeptides and different comparable professional- teins were cloned, and the rules of expression of those genes has been studied broadly. Transgenic animals were utilized in learning the functionality of the gene in que- stion. In-situ hybridization is being utilized to localize the location of construction and learn the rules of professional- duction of peptides or proteins.

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8. Effect of cycloheximide on GR mRNA levels. S flglml cycloheximide. l 100 o 123456 Time(hr) 24 Y. Dong, S. -A. Gustafsson 28 mRNA level about four-fold. This effect rapidly reached a maximal response after 4 h and was maintained for at least 24 h (Fig. 8). 2 cells, cycloheximide also increased GR mRNA about four-fold (Fig. 9). It is tempting to speculate that a short-lived repressor-like protein is controlling the basal level of expression of the GR gene in rat hepatoma cells. Removal of this protein by cycloheximide increases the transcriptional activity of the GR gene.

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